Our ReSOLVE™ platform enables a highly differentiated pipeline of small molecule therapeutics for highly validated innate immunity targets. Our lead programs target the inflammasome and nucleic acid sensing pathways. We have multiple programs in discovery and are pursuing a broad pipeline of additional targets.

Pipeline

ProgramDiscoveryIND-EnablingPhase 1Phase 2Phase 3
VENT-03 (Oral cGAS inhibitor)
Lupus
Treatment-Refractory Rheumatoid Arthritis
VENT-02 (Oral brain-penetrant NLRP3 inhibitor)
Parkinson’s Disease
Osteoarthritis in Obese Patients
VENT-01 (Oral systemic NLRP3 inhibitor)
Broad range of systemic diseases
novo nordisk
Multiple programs in discovery, powered by ReSOLVE®
VENT-03 (Oral cGAS inhibitor)
Lupus
Phase 1
3.05_Phase 1:6:0.61
Treatment-Refractory Rheumatoid Arthritis
Phase 1
3.05_Phase 1:6:0.61
VENT-02 (Oral brain-penetrant NLRP3 inhibitor)
Parkinson’s Disease
Phase 2
3.55_Phase 1:6:0.71
Osteoarthritis in Obese Patients
Phase 1
3.05_Phase 1:6:0.61
VENT-01 (Oral systemic NLRP3 inhibitor)
Broad range of systemic diseases
Phase 1
2.55_IND-Enabling:6:0.51

novo nordisk
Multiple programs in discovery, powered by ReSOLVE®