Ventus founders and advisors noted in green.

Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis.
Wang K, Sun Q, Zhong X, Zeng M, Zeng H, Shi X, Li Z, Wang Y, Zhao Q, Shao F, Ding J.
Cell. 2020 Mar 5;180(5):941-955.

Molecular mechanism for NLRP6 inflammasome assembly and activation.
Shen C, Lu A, Xie WJ, Ruan J, Negro R, Egelman EH, Fu TM, Wu H.
Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2052-2057.

Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression.
Lama L, Adura C, Xie W, Tomita D, Kamei T, Kuryavyi V, Gogakos T, Steinberg JI, Miller M, Ramos-Espiritu L, Asano Y, Hashizume S, Aida J, Imaeda T, Okamoto R, Jennings AJ, Michino M, Kuroita T, Stamford A, Gao P, Meinke P, Glickman JF, Patel DJ, Tuschl T.
Nat Commun. 2019 May 21;10(1):2261.

Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome.
Sharif H, Wang L, Wang WL, Magupalli VG, Andreeva L, Qiao Q, Hauenstein AV, Wu Z, Núñez G, Mao Y, Wu H.
Nature. 2019 Jun;570(7761):338-343.

Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation.
Xie W, Lama L, Adura C, Tomita D, Glickman JF, Tuschl T, Patel DJ.
Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11946-11955.

Cryo-EM structure of the gasdermin A3 membrane pore.
Ruan J, Xia S, Liu X, Lieberman JWu H.
Nature. 2018 May;557(7703):62-67.

Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells.
Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm NW, Yang Y, Yu H, Li HB, Wang G, Lei X, de Zoete MR, Zhao J, Zheng Y, Chen H, Zhao Y, Jurado KA, Feng N, Shan L, Kluger Y, Lu J, Abraham C, Fikrig E, Greenberg HB, Flavell RA.
Nature. 2017 Jun 29;546(7660):667-670.

Pore-forming activity and structural autoinhibition of the gasdermin family.
Ding J, Wang K, Liu W, She Y, Sun Q, Shi J, Sun H, Wang DC, Shao F.
Nature. 2016 Jul 7;535(7610):111-6.

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores.
Liu X, Zhang Z, Ruan J, Pan Y, Magupalli VG, Wu HLieberman J.
Nature. 2016 Jul 7;535(7610):153-8.

The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury.
Hu B, Jin C, Li HB, Tong J, Ouyang X, Cetinbas NM, Zhu S, Strowig T, Lam FC, Zhao C, Henao-Mejia J, Yilmaz O, Fitzgerald KA, Eisenbarth SC, Elinav E, Flavell RA.
Science. 2016 Nov 11;354(6313):765-76

Functional degradation: A mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes.
Sandstrom, A., Mitchell, P.S., Goers, L., Mu, E.W., Lesser, C.F., and Vance, R.E. (2019).
Science. 2019 Apr 5;364(6435).

Gasdermin E suppresses tumour growth by activating anti-tumour immunity.
Zhang, Z., Zhang, Y., Xia, S., Kong, Q., Li, S., Liu, X., Junqueira, C., Meza-Sosa, K.F., Mok, T.M.Y., Ansara, J., et al. (2020).
Nature. 2020 Mar; 579(7799):415-420.

A bioorthogonal system reveals antitumour immune function of pyroptosis.
Wang, Q., Wang, Y., Ding, J., Wang, C., Zhou, X., Gao, W., Huang, H., Shao, F., and Liu, Z.
Nature. 2020 Mar;579(7799):421-426.