Senior/Principal Scientist, Medicinal Chemistry

Montreal, QC

About Us

Ventus is a well funded, Versant Ventures and GV (formerly Google Ventures)-backed biotech company with an initial focus directed toward innovative small molecule therapeutics targeting key innate immune pathways, and was recently named one of the 10 “Start-ups to Watch” for 2020 by Chemical and Engineering News.  Ventus was founded by scientific thought leaders in structural immunology and innate immunity who discovered that innate immune signaling leads to the formation of multimeric complexes that drive the subsequent inflammatory cascade. Leveraging the expertise of our founders, Ventus has quickly become the leader in pursuing biochemical and structure-based drug discovery for highly sought-after targets of the innate immune system. Crucial to these efforts was the establishment of our proprietary physics-based ReSolve computational platform, our industry-leading approach for describing the solvation state of a protein in motion. Looking to the future, Ventus will be expanding our pipeline through application of our structural biology and computational platforms to the rational discovery of small molecule therapeutics beyond innate immunity. To learn more about Ventus Therapeutics visit 

A Unique Opportunity in a Fast-growing Organization

Ventus is seeking a highly motivated experienced medicinal chemist to join our Chemistry team. We are looking for a talented, collaborative and dynamic scientist to support our research efforts, and help us build out our pipeline of preclinical programs. This role is a unique opportunity to contribute to a well-funded start-up, using breakthrough science to drug previously challenging targets. 

Primary Responsibilities

  • Drive medicinal chemistry campaigns from hit identification to candidate selection
  • Proactively incorporate modern structure-based drug design concepts into medicinal chemistry strategy and compound design.
  • Plan and execute efficient, multi-step syntheses of molecules designed to advance project and interrogate medicinal chemistry hypotheses
  • Manage external resources to achieve project goals

Minimum Requirements

  • D. with 5+ years of experience or M.Sc. with 10+ years of experience in biotechnology and/or pharma companies
  • Track record of innovation and impact on drug discovery programs documented through co-inventorship on issued patents, patent applications and authorship of publications in peer-reviewed journals
  • Excellent oral and written communication skills; ability to work both independently and within a team
  • Ability to meet complex objectives under aggressive timelines in a rapidly changing environment
  • Excellent communication, organizational and interpersonal skills
  • Proficient in analyzing data, and addressing technical challenges using analytical and problem-solving skills

Preferred Experience and Skills:

  • Proficiency in modern structure-based drug design techniques
  • Naturally collaborative approach to solving complex, multidisciplinary scientific problems
  • Prior experience in immunology, immuno-oncology or neurodegeneration is an asset

Ventus offers competitive benefits and compensation programs including incentive-based stock and cash bonus programs in addition to a collaborative, academic and scientific based culture.  If you would like to contribute to cutting edge science and be part of an innovative and team based company, send CVs to