Scientist, Protein Biochemistry

Waltham, MA

About Us

Ventus is a well funded, Versant Ventures and GV (formerly Google Ventures)-backed biotech company with an initial focus directed toward innovative small molecule therapeutics targeting key innate immune pathways.  Ventus was founded by scientific thought leaders in structural immunology and innate immunity who discovered that innate immune signaling leads to the formation of multimeric complexes that drive the subsequent inflammatory cascade.  Leveraging the expertise of our founders, Ventus has quickly become the leader in pursuing biochemical and structure-based drug discovery for highly sought-after targets of the innate immune system. Crucial to these efforts was the establishment of our proprietary physics-based ReSolve computational platform, our industry-leading approach for describing the solvation state of a protein in motion. Looking to the future, Ventus will be expanding our pipeline through application of our structural biology and computational platforms to the rational discovery of small molecule therapeutics beyond innate immunity. To learn more about Ventus Therapeutics visit

Position Overview

Ventus is seeking a highly motivated scientist to join the Protein Sciences team. This individual will collaborate with other scientists and cross-functional team members in order to advance drug discovery projects. They will work independently, as well as part of a multi-disciplinary research team focused on protein engineering/expression/purification in support of biochemical, biophysical and structural biology studies.

Key Responsibilities

  • Engineer, express and purify recombinant proteins for assay development and structural biology studies
  • Develop and implement a range of biochemical and biophysical assays to support investigation of a diverse range of target classes
  • Integral member of project teams, contributing to the scientific direction of programs
  • Excellent time management skills and an ability to work in a fast-paced team-based environment
  • Excellent interpersonal skills and the ability to communicate/collaborate with teams and colleagues to meet experimental and organizational goals
  • Contribute to the discovery and development of novel clinical drug candidates

Minimum Requirements

  • PhD (0-1 year), MS (3-5 years), or BS (10+ years) in Biochemistry/Biophysics in protein expression/purification and assay development; biotechnology and/or pharma experience preferred
  • Technical expertise in protein engineering, production, and purification from E. coli, insect cell, and mammalian expression systems
  • Previous experience characterizing protein-ligand interactions by biophysical methods. Strong working knowledge of techniques such as ITC, SPR, TSA, MST, etc.
  • Experience in the development of biochemical assays including TR-FRET, ELISA, MSD.
  • Experience collaborating with external vendors
  • Demonstrated excellence in protein biochemistry supported by publication in top tier journals
  • Innovative, entrepreneurial, and enjoys working in a fast-paced, small-company environment
  • Excellent written and verbal communication skills

Ventus offers competitive benefits and compensation programs including incentive based stock and cash bonus programs in addition to a collaborative, academic and scientific based culture.  If you would like to contribute to cutting edge science and be part of an innovative and team based company, send CVs to