Director, Medicinal Chemistry

Montreal, QC

About Us

Ventus is a well funded, Versant Ventures and GV (formerly Google Ventures)-backed biotech company with an initial focus directed toward innovative small molecule therapeutics targeting key innate immune pathways, and was recently named one of the 10 “Start-ups to Watch” for 2020 by Chemical and Engineering News.  Ventus was founded by scientific thought leaders in structural immunology and innate immunity who discovered that innate immune signaling leads to the formation of multimeric complexes that drive the subsequent inflammatory cascade. Leveraging the expertise of our founders, Ventus has quickly become the leader in pursuing biochemical and structure-based drug discovery for highly sought-after targets of the innate immune system. Crucial to these efforts was the establishment of our proprietary physics-based ReSolve computational platform, our industry-leading approach for describing the solvation state of a protein in motion. Looking to the future, Ventus will be expanding our pipeline through application of our structural biology and computational platforms to the rational discovery of small molecule therapeutics beyond innate immunity. To learn more about Ventus Therapeutics visit 

A Unique Opportunity in a Fast-growing Organization

Ventus is seeking a highly motivated experienced medicinal chemist to join our Chemistry team. We are looking for a talented, collaborative and dynamic scientist to support our research efforts, and help us build out our pipeline of preclinical programs. This role is a unique opportunity to contribute to a well-funded start-up, using breakthrough science to drug previously challenging targets. 

Primary Responsibilities

  • Lead the medicinal chemistry efforts, from hit identification to candidate selection, for one or more of our pipeline projects
  • Provide chemistry input during the target selection stage for targets under consideration for pipeline expansion
  • Work with our computational chemistry and structural biology departments to develop and validate binding models used for rational design
  • Manage internal and external resources to achieve project goals

Minimum Requirements

  • D. with 10+ years of experience or M.Sc. with 15+ years of experience in biotechnology and/or pharma companies
  • Demonstrated experience leading medicinal chemistry programs into the clinic
  • Demonstrated ability to manage external teams efficiently
  • Broad scientific experience as evidenced by a strong publication record and numerous filed/granted patent applications across multiple programs
  • Excellent oral and written communication skills; ability to work both independently and within a team
  • Ability to meet complex objectives under aggressive timelines in a rapidly changing environment
  • Excellent organization, communication and interpersonal skills
  • Proficient in analyzing data, and addressing technical challenges using analytical and problem-solving skills

Preferred Experience and Skills

  • Proficiency in modern structure-based drug design techniques
  • Experience driving programs with affinity-based methods such as SPR
  • Prior experience in immunology, immuno-oncology or neurodegeneration is an asset

Ventus offers competitive benefits and compensation programs including incentive based stock and cash bonus programs in addition to a collaborative, academic and scientific based culture.  If you would like to contribute to cutting edge science and be part of an innovative and team based company, send CVs to